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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8e74280e39c888b14bb30a10429276ad1d6d74361eabf2951f917e36d842ae43' 
  AND token = 'r2yJIYwBPoExybNr59PEWYVkqwsGk4G+zTG5Gz021w4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}