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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d07807792da9ef360ced6920b179f2226039c2b9b80a4db78df48cb5d76b16a' 
  AND token = 'bqFR3KSXXO8zERI6NTZ+pAftUGU5hPdUOTLUbAt5Ess=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}