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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '00ed95f7125ab37a3aaf9f7f689d4eb93109d3c31af2bd53c302d46262863303' 
  AND token = 'nvek/pLgj39ksDU8qBH6p0hTp0lTyH0/IXYlG7eMy0k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}