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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2cd59ee1f9af4021861139d5d14b82cc42135012d0d58080db69a139773d857a' 
  AND token = 'XrLdRSDBKlyUQ8K/kv5bBMlMxZuE1E+/3lsjgnA2f34=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}