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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16418ae1a81c5029e83ca39506470976b9908c9e22118d2625177d4ad356436c' 
  AND token = 'UG75B/KBeEW+4RtyptEPr78zdJy+tDsNo3Kha5/0Q00=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}