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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5defa4f1df68b085e58d60c2c8d9c0a092a5bc306fd8c9eac4fef3c87a27dcaa' 
  AND token = 'ZAUkrq/hHC3ivjw62gj2MGwXTenmk4pCAzjEOVGTVCU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}